Across TCGA patient cohorts, KRT222 mutation is significantly associated with the RNA expression of many other genes, with 668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT222-associated genes across cancer lineages are RNU6-1213P, LINC02559, and RNU6-380P. Each is linked with KRT222 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT222-to-partner and partner-to-KRT222 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT222→partner) and Y-score (partner→KRT222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1213P →	+0.343	+7.924	<.001	.008	3	3
SKCM	LINC02559 →	+0.050	+3.209	<.001	.004	3	3
UCEC	RNU6-380P →	+0.156	+4.010	<.001	.007	3	3
BRCA	TTTY7B →	+0.016	+7.471	<.001	.008	3	2
SKCM	RBM17P2 →	+0.014	+2.507	.001	.001	3	2
UCEC	MIR4510 →	+0.225	+3.716	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 668 associations by consensus.

Exploration

KRT222 survival (RNA) · tumor vs normal (RNA) · all KRT222 data types