Across TCGA pan-cancer cohorts, KRT222 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of KRT222’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KRT222 RNA is repressed in tumor relative to normal tissue. In most cancer types KRT222 is over-expressed in tumor, although a few such as BLCA and HNSC show the opposite, repressed pattern.
BLCA, HNSC, and KICH are the cancer types where KRT222 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT222 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.