Across TCGA patient cohorts, KRT222 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT222-associated genes across cancer lineages are Caspase-7-cleavedD198, Myosin-IIa_pS1943, and ERK2. Each is linked with KRT222 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT222-to-partner and partner-to-KRT222 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT222→partner) and Y-score (partner→KRT222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.039	+3.321	<.001	.010	3	2
SKCM	Myosin-IIa_pS1943 →	+0.274	+3.602	.042	.001	3	2
UCEC	ERK2 →	+0.297	+2.999	.003	.035	3	1
UCEC	MIG-6 →	+0.132	+3.009	.011	.019	3	1
UCEC	Notch1 →	+0.159	+2.817	.031	.036	3	1
UCEC	PCNA →	+0.403	+3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

KRT222 survival (RNA) · tumor vs normal (RNA) · all KRT222 data types