KRT20

Across TCGA patient cohorts, KRT20 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT20-associated genes across cancer lineages are ATM, Cyclin-D1, and eIF4G. Each is linked with KRT20 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT20-to-partner and partner-to-KRT20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KRT20-low versus KRT20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT20→partner) and Y-score (partner→KRT20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.416	-3.156	.026	.018	3	2
SKCM	Cyclin-D1 →	+0.355	+3.459	.001	.005	3	2
UCEC	eIF4G →	+0.255	+1.807	.047	.027	3	1
UCEC	MEK1 →	+0.337	+2.584	.025	.010	3	1
UCEC	Notch1 →	+0.127	+1.807	.029	.027	3	1
UCEC	Annexin-1 →	+0.644	+2.604	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by KRT20 expression — UCEC

Explore this box plot interactively →