KRT20

Across TCGA pan-cancer cohorts, KRT20 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KRT20 data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRT20 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRT20 expression acts as an unfavorable survival marker, although some lineages such as SCLC and ACC show a favorable association.

HNSC, KIRP, and LIHC are the cancer types where KRT20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.394	0.728	<.001	75	view →
KIRP	DFS	Tertile	All	0.544	0.801	.001	59	view →
LIHC	DFS	Tertile	All	0.341	0.493	.002	49	view →
UVM	OS	Tertile	All	0.589	0.945	.006	27	view →
MESO	OS	Tertile	All	0.186	0.597	.010	24	view →
SCLC	OS	Quartile	II,III,IV	0.799	0.373	.004	20	view →
UCEC	OS	Quartile	All	0.628	0.791	.003	20	view →
LUAD	DFS	Tertile	All	0.260	0.463	<.001	20	view →
PAAD	OS	Median	All	0.481	0.689	.006	18	view →
ACC	DFS	Quartile	II,III,IV	0.766	0.320	.006	16	view →
ESCA	DFS	Median	All	0.584	0.375	.002	15	view →
STAD	DFS	Median	IV	0.171	0.670	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KRT20–HNSC (OS)

Open the HNSC breakdown →