KRT18P58

Across TCGA pan-cancer cohorts, KRT18P58 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KRT18P58’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where KRT18P58 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT18P58 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LUAD, STAD, and KIRC are the cancer types where KRT18P58 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT18P58 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.087	<.001	8	view →
STAD	All	All	+0.112	<.001	6	view →
KIRC	Male	All	+0.023	.001	6	view →
BLCA	All	All	+0.042	.026	5	view →
COAD	All	II,III,IV	+0.094	.004	4	view →
BRCA	Female	II,III,IV	+0.018	.016	4	view →
LUSC	All	All	+0.055	.001	3	view →
PAAD	Female	All	+0.150	.004	2	view →
CHOL	Female	All	+0.070	.014	2	view →
THCA	Female	III,IV	−0.037	.006	2	view →
HNSC	All	IV	+0.049	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KRT18P58–LUAD

Open the LUAD breakdown →