KRT18

Across TCGA patient cohorts, KRT18 protein abundance is significantly associated with the RNA expression of many other genes, with 12,959 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KRT18-associated genes across cancer lineages are KRT8, KRT18P28, and SLC25A21. Each is linked with KRT18 in more than 8 cancer types. Because this analysis shows association rather than direction, both KRT18-to-partner and partner-to-KRT18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KRT18 versus KRT8 in HNSC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT18→partner) and Y-score (partner→KRT18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KRT8 →	+2.014	+0.561	<.001	<.001	3	9
BRCA	KRT18P28 →	+0.650	+0.722	.008	.001	3	6
HNSC	SLC25A21 →	+0.535	+0.560	<.001	<.001	3	5
COAD	KRT18P11 →	+0.719	+0.555	<.001	<.001	3	5
PDAC	KRT87P →	+0.906	+0.591	<.001	<.001	3	5
UCEC	SLC44A3 →	+1.175	+0.394	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,959 associations by consensus.

KRT18 vs KRT8 — HNSC

Explore this scatter interactively →