KRT18

Across TCGA pan-cancer cohorts, KRT18 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KRT18 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KRT18 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRT18 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

LUAD, PAAD, and LGG are the cancer types where KRT18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.575	0.744	<.001	89	view →
PAAD	OS	Tertile	All	0.313	0.585	.001	71	view →
LGG	OS	Median	All	0.850	0.938	<.001	48	view →
ESCA	OS	Tertile	All	0.436	1.000	.008	27	view →
UCEC	OS	Median	III,IV	0.701	0.475	.015	24	view →
SCLC	OS	Median	All	0.401	0.135	.005	19	view →
STAD	DFS	Quartile	II,III,IV	0.727	0.517	.009	17	view →
BRCA	OS	Median	III,IV	0.945	0.862	.006	16	view →
COAD	DFS	Quartile	II,III,IV	0.548	0.752	.002	15	view →
ACC	DFS	Tertile	III,IV	0.611	0.360	.006	14	view →
SARC	OS	Quartile	All	0.595	0.837	.003	14	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KRT18–LUAD (DFS)

Open the LUAD breakdown →