KRT18

Across TCGA patient cohorts, KRT18 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT18-associated genes across cancer lineages are Myosin-IIa_pS1943, PDCD4, and Rab25. Each is linked with KRT18 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT18-to-partner and partner-to-KRT18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by KRT18-low versus KRT18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT18→partner) and Y-score (partner→KRT18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.295	+3.013	.013	.019	3	1
UCEC	PDCD4 →	-0.564	-3.000	.038	.037	3	1
UCEC	Rab25 →	-0.586	-3.000	.002	.037	3	1
UCEC	p62 Lck ligand →	+0.373	+3.000	.047	.037	1	1
UCEC	PCNA →	+0.323	+3.000	.009	.037	1	1
UCEC	Rad50 →	-0.306	-3.000	.029	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Myosin-IIa_pS1943 by KRT18 expression — UCEC

Explore this box plot interactively →