KRT15

Across TCGA patient cohorts, KRT15 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT15-associated genes across cancer lineages are MEK1, Rab25, and Caspase-7-cleavedD198. Each is linked with KRT15 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT15-to-partner and partner-to-KRT15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by KRT15-low versus KRT15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT15→partner) and Y-score (partner→KRT15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.286	+2.169	.037	.003	3	2
UCEC	Rab25 →	-0.331	-2.999	.007	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.681	+1.604	.002	.041	3	2
UCEC	IGFBP2 →	-0.770	-2.000	.001	.030	3	1
UCEC	JNK2 →	+0.181	+1.415	.015	.046	3	1
UCEC	MSH2 →	-0.249	-3.433	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by KRT15 expression — UCEC

Explore this box plot interactively →