KRR1

Across TCGA patient cohorts, KRR1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRR1-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and GATA6. Each is linked with KRR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRR1-to-partner and partner-to-KRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KRR1-low versus KRR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRR1→partner) and Y-score (partner→KRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.270	-2.807	.013	.003	3	1
UCEC	FoxM1 →	+0.236	+2.115	.037	.019	3	1
UCEC	GATA6 →	-0.206	-2.577	.004	.011	3	1
UCEC	Heregulin →	-0.150	-3.584	.005	.002	3	1
UCEC	JNK2 →	+0.375	+3.710	<.001	<.001	3	1
UCEC	Ku80 →	+0.259	+2.179	.012	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by KRR1 expression — UCEC

Explore this box plot interactively →