KRR1

Across TCGA pan-cancer cohorts, KRR1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KRR1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where KRR1 RNA is repressed in tumor relative to normal tissue. In most cancer types KRR1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where KRR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.512	<.001	9	view →
HNSC	All	III,IV	+0.430	.003	7	view →
LIHC	All	All	+0.372	<.001	7	view →
CHOL	All	II,III,IV	+1.284	<.001	5	view →
COAD	Male	All	+0.464	<.001	4	view →
BLCA	All	III,IV	+0.375	.017	4	view →
LUSC	Male	All	+0.374	<.001	4	view →
STAD	All	II,III,IV	+0.499	.012	3	view →
KICH	Female	All	−0.550	.041	2	view →
UCEC	All	All	−0.468	.010	2	view →
ESCA	All	All	+0.458	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KRR1–THCA

Open the THCA breakdown →