KRR1

Across TCGA cell cohorts, KRR1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRR1-associated genes across cancer lineages are MAGEB5, OR2M5, and PLA2G2E. Each is linked with KRR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRR1-to-partner and partner-to-KRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by KRR1-low versus KRR1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRR1→partner) and Y-score (partner→KRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
SOFT_TISSUE	OR2M5 →	+0.017	+4.369	<.001	.008	3	1
BREAST	PLA2G2E →	+0.036	+5.781	<.001	.001	3	1
BREAST	C3orf84 →	+0.058	+5.169	<.001	.005	3	1
OVARY	GHRH →	+0.296	+5.196	<.001	.005	3	1
OVARY	MLN →	+0.890	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MAGEB5 by KRR1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →