KREMEN2

Across TCGA patient cohorts, KREMEN2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KREMEN2-associated genes across cancer lineages are MIR6766, RNU6-281P, and OR4K3. Each is linked with KREMEN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KREMEN2-to-partner and partner-to-KREMEN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6766 grouped by KREMEN2-low versus KREMEN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KREMEN2→partner) and Y-score (partner→KREMEN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6766 →	+0.832	+5.358	<.001	.006	3	1
SKCM	RNU6-281P →	+0.373	+7.816	<.001	.008	3	1
UCEC	OR4K3 →	+0.140	+5.081	<.001	.008	3	1
UCEC	MIR4747 →	+0.982	+5.133	<.001	.008	3	1
UCEC	MIR5588 →	+0.968	+5.081	<.001	.008	3	1
UCEC	RN7SKP204 →	+0.761	+4.982	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MIR6766 by KREMEN2 expression — UCEC

Explore this box plot interactively →