KRBOX1

Across TCGA pan-cancer cohorts, KRBOX1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KRBOX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KRBOX1 RNA is repressed in tumor relative to normal tissue. In most cancer types KRBOX1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where KRBOX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRBOX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.625	<.001	12	view →
KICH	Male	II,III,IV	−0.864	<.001	8	view →
UCEC	All	III,IV	−1.048	<.001	6	view →
BRCA	Female	II,III,IV	−0.513	<.001	6	view →
STAD	Male	All	−0.485	.001	4	view →
HNSC	All	III,IV	−0.295	.004	4	view →
COAD	Female	III,IV	−0.288	<.001	3	view →
LUAD	All	IV	+1.325	.008	2	view →
PRAD	All	All	−0.394	<.001	2	view →
ESCA	All	II,III,IV	−0.380	.049	2	view →
THCA	All	All	−0.379	.005	2	view →
READ	Female	All	−0.644	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KRBOX1–KIRC

Open the KIRC breakdown →