Across TCGA patient cohorts, KPRP mutation is significantly associated with the RNA expression of many other genes, with 6,278 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPRP-associated genes across cancer lineages are PSMD12, SRRD, and HMGXB4. Each is linked with KPRP in more than 4 cancer types. Because this analysis shows association rather than direction, both KPRP-to-partner and partner-to-KPRP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPRP→partner) and Y-score (partner→KPRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD12 →	+0.390	+2.850	<.001	<.001	3	5
LUAD	SRRD →	+0.456	+2.718	<.001	.003	3	5
LUAD	HMGXB4 →	+0.495	+1.942	<.001	.009	3	5
LUAD	GMNN →	+0.649	+2.593	<.001	.006	3	5
LUAD	ADPRS →	+0.351	+3.111	.003	<.001	3	5
UCEC	PSMC3IP →	+0.651	+2.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,278 associations by consensus.

Exploration

KPRP survival (RNA) · tumor vs normal (RNA) · all KPRP data types