Across TCGA patient cohorts, KPRP mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPRP-associated genes across cancer lineages are 4E-BP1, Dvl3, and EGFR_pY1068. Each is linked with KPRP in more than 3 cancer types. Because this analysis shows association rather than direction, both KPRP-to-partner and partner-to-KPRP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPRP→partner) and Y-score (partner→KPRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.332	+2.999	<.001	<.001	3	4
LUAD	Dvl3 →	+0.188	+2.700	.002	.005	3	3
UCEC	EGFR_pY1068 →	-0.221	-2.584	.004	.001	3	3
UCEC	p62 Lck ligand →	+0.340	+3.087	<.001	<.001	3	3
COAD	Shc_pY317 →	-0.208	-2.991	<.001	<.001	3	3
COAD	MSH6 →	+0.330	+1.874	.023	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

KPRP survival (RNA) · tumor vs normal (RNA) · all KPRP data types