KPNA6

Across TCGA pan-cancer cohorts, KPNA6 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KPNA6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where KPNA6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KPNA6 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUAD, COAD, and LSCC are the cancer types where KPNA6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KPNA6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.146	<.001	7	view →
COAD	All	All	−0.100	<.001	7	view →
LSCC	All	All	+0.087	<.001	5	view →
HNSC	All	III,IV	+0.091	.029	3	view →
CCRCC	All	II,III,IV	+0.072	.017	3	view →
OV	All	All	+0.316	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KPNA6–LUAD

Open the LUAD breakdown →