KPNA6

Across TCGA pan-cancer cohorts, KPNA6 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KPNA6 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher KPNA6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KPNA6 expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRC show a favorable association.

SCLC, LGG, and KIRC are the cancer types where KPNA6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	III,IV	0.707	0.343	.001	55	view →
LGG	DFS	Tertile	All	0.672	0.851	<.001	50	view →
KIRC	DFS	Tertile	All	0.791	0.489	<.001	46	view →
LIHC	DFS	Median	All	0.475	0.606	<.001	44	view →
ACC	DFS	Quartile	All	0.429	0.888	<.001	39	view →
BLCA	DFS	Quartile	II,III,IV	0.454	0.614	.007	32	view →
MESO	DFS	Median	IV	0.189	0.521	.002	22	view →
KICH	DFS	Median	II,III,IV	0.571	0.920	.005	20	view →
READ	DFS	Quartile	All	0.904	0.258	.011	17	view →
HNSC	OS	Tertile	III,IV	0.557	0.827	.006	13	view →
CHOL	OS	Median	II,III,IV	1.000	0.463	.012	12	view →
OV	DFS	Quartile	IV	0.345	0.559	.042	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KPNA6–SCLC (DFS)

Open the SCLC breakdown →