KPNA6

Across TCGA patient cohorts, KPNA6 mutation is significantly associated with the RNA expression of many other genes, with 5,161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPNA6-associated genes across cancer lineages are MRPS10P1, ATP6V1G1P1, and PSMA6. Each is linked with KPNA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA6-to-partner and partner-to-KPNA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS10P1 grouped by KPNA6-low versus KPNA6-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA6→partner) and Y-score (partner→KPNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MRPS10P1 →	+0.403	+5.182	<.001	.007	3	2
HNSC	ATP6V1G1P1 →	+0.189	+5.822	<.001	.003	3	2
UCEC	PSMA6 →	+0.571	+4.095	<.001	<.001	3	2
SKCM	PRPS2 →	+0.884	+3.341	.003	.005	3	2
SKCM	MRPL18 →	+0.672	+3.353	<.001	.005	3	2
SKCM	TBP →	+0.602	+3.182	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,161 associations by consensus.

MRPS10P1 by KPNA6 expression — HNSC

Explore this box plot interactively →