KPNA6

Across TCGA cell cohorts, KPNA6 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible KPNA6-associated genes across cancer lineages are PRAMEF10, PRAMEF20, and PRAMEF17. Each is linked with KPNA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA6-to-partner and partner-to-KPNA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by KPNA6-low versus KPNA6-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA6→partner) and Y-score (partner→KPNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PRAMEF10 by KPNA6 expression — LUNG_SCLC

Explore this box plot interactively →