Across TCGA patient cohorts, KPNA5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPNA5-associated genes across cancer lineages are ATM, EGFR_pY1068, and EGFR. Each is linked with KPNA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA5-to-partner and partner-to-KPNA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA5→partner) and Y-score (partner→KPNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.644	-2.415	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.279	-3.459	.005	.005	3	1
UCEC	EGFR →	-0.155	-2.321	.016	.034	3	1
UCEC	A-Raf_pS299 →	-0.159	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.199	+2.459	.010	.018	3	1
UCEC	FoxM1 →	+0.220	+1.906	.034	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

KPNA5 survival (RNA) · tumor vs normal (RNA) · all KPNA5 data types