Across TCGA pan-cancer cohorts, KPNA5 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated KPNA5 data layer compared with 4 for mutation status and 1 for mass-spec protein.
The strongest signal is observed in uterine carcinosarcoma (UCS), where higher KPNA5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KPNA5 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.
UCS, LIHC, and SKCM are the cancer types where KPNA5 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.