Across TCGA cell cohorts, KPNA5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KPNA5-associated genes across cancer lineages are SUPT20HL1, USP17L4, and SPATS1. Each is linked with KPNA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KPNA5-to-partner and partner-to-KPNA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA5→partner) and Y-score (partner→KPNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SUPT20HL1 →	+0.096	+4.807	<.001	.006	3	1
BLOOD_Myeloma	USP17L4 →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPATS1 →	+0.353	+4.807	<.001	.006	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

KPNA5 survival (RNA) · tumor vs normal (RNA) · all KPNA5 data types