KPNA1

Across TCGA pan-cancer cohorts, KPNA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KPNA1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KPNA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KPNA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where KPNA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.497	0.916	.003	44	view →
HNSC	OS	Median	IV	0.864	0.612	.006	13	view →
LSCC	OS	Median	All	1.000	0.926	.015	10	view →
GBM	DFS	Tertile	All	0.237	0.440	.024	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
PDAC	OS	Tertile	III,IV	0.186	0.503	.028	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KPNA1–CCRCC (DFS)

Open the CCRCC breakdown →