KPNA1

Across TCGA patient cohorts, KPNA1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KPNA1-associated genes across cancer lineages are GAPDH, EGFR_pY1068, and ERK2. Each is linked with KPNA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KPNA1-to-partner and partner-to-KPNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by KPNA1-low versus KPNA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KPNA1→partner) and Y-score (partner→KPNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.355	+1.584	.030	.032	3	3
UCEC	EGFR_pY1068 →	-0.300	-2.222	<.001	<.001	3	2
UCEC	ERK2 →	+0.170	+1.263	.003	.019	3	2
UCEC	Shc_pY317 →	-0.176	-2.070	<.001	.001	3	2
UCEC	ASNS →	+0.359	+1.321	.001	.027	3	2
UCEC	ATM →	-0.618	-3.074	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

GAPDH by KPNA1 expression — UCEC

Explore this box plot interactively →