Across TCGA patient cohorts, KNTC1 mutation is significantly associated with the RNA expression of many other genes, with 3,875 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNTC1-associated genes across cancer lineages are TEDC1, FEN1, and YARS1. Each is linked with KNTC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both KNTC1-to-partner and partner-to-KNTC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNTC1→partner) and Y-score (partner→KNTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TEDC1 →	+0.295	+1.501	.007	.001	3	5
UCEC	FEN1 →	+0.423	+1.584	.001	.002	3	5
CESC	YARS1 →	+0.419	+3.614	.004	.001	3	4
LUAD	PSME3 →	+0.463	+2.723	<.001	.003	3	4
COAD	PKM →	+0.550	+2.598	.003	.006	3	4
UCEC	ZFPM1 →	+0.316	+2.139	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,875 associations by consensus.

Exploration

KNTC1 survival (RNA) · tumor vs normal (RNA) · all KNTC1 data types