KNOP1

Across TCGA pan-cancer cohorts, KNOP1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated KNOP1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KNOP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KNOP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where KNOP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.696	0.843	.008	29	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.770	.017	20	view →
CCRCC	DFS	Tertile	III,IV	0.422	1.000	.031	13	view →
LUAD	DFS	Median	III,IV	0.804	0.238	.001	13	view →
PDAC	OS	Median	II,III,IV	0.268	0.437	.008	9	view →
OV	DFS	Median	All	0.970	0.624	.046	4	view →
UCEC	DFS	Median	II,III,IV	0.880	0.535	.040	4	view →
GBM	OS	Tertile	All	0.599	0.302	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

KNOP1–HNSC (DFS)

Open the HNSC breakdown →