KNOP1

Across TCGA pan-cancer cohorts, KNOP1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of KNOP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KNOP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KNOP1 is over-expressed in tumor.

HNSC, KIRC, and BLCA are the cancer types where KNOP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KNOP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.878	<.001	12	view →
KIRC	Female	All	+0.593	<.001	12	view →
BLCA	Male	III,IV	+1.670	<.001	11	view →
KIRP	All	IV	+1.380	<.001	11	view →
STAD	Female	All	+1.291	<.001	11	view →
COAD	All	III,IV	+0.762	<.001	10	view →
LUAD	All	III,IV	+1.147	<.001	9	view →
LIHC	Female	II,III,IV	+1.073	<.001	9	view →
LUSC	Female	All	+1.404	<.001	8	view →
THCA	Male	All	+0.504	<.001	8	view →
BRCA	All	II,III,IV	+0.911	<.001	6	view →
UCEC	All	All	+0.552	.005	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

KNOP1–HNSC

Open the HNSC breakdown →