KNOP1

Across TCGA patient cohorts, KNOP1 mutation is significantly associated with the RNA expression of many other genes, with 1,809 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNOP1-associated genes across cancer lineages are RNA5SP420, SNRPD3, and NUTF2. Each is linked with KNOP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KNOP1-to-partner and partner-to-KNOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP420 grouped by KNOP1-low versus KNOP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNOP1→partner) and Y-score (partner→KNOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP420 →	+0.557	+2.189	<.001	.002	3	3
UCEC	SNRPD3 →	+0.393	+3.724	.002	<.001	3	2
UCEC	NUTF2 →	+0.396	+3.119	.001	<.001	3	2
UCEC	NUP93 →	+0.437	+3.601	.005	.001	3	2
UCEC	ACD →	+0.543	+3.119	<.001	<.001	3	2
UCEC	OAZ1 →	+0.486	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,809 associations by consensus.

RNA5SP420 by KNOP1 expression — UCEC

Explore this box plot interactively →