KNOP1

Across TCGA cell cohorts, KNOP1 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KNOP1-associated genes across cancer lineages are DSC1, PIP, and OR2T35. Each is linked with KNOP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KNOP1-to-partner and partner-to-KNOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSC1 grouped by KNOP1-low versus KNOP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNOP1→partner) and Y-score (partner→KNOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DSC1 →	+0.708	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	PIP →	+0.139	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	OR2T35 →	+0.056	+3.523	.004	.009	3	1
BLOOD_Lymphoma	SELE →	+0.035	+4.765	<.001	<.001	3	1
LARGE_INTESTINE	LHX2 →	+0.846	+3.304	.001	.005	3	1
LARGE_INTESTINE	TFAP2E →	+0.849	+3.064	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

DSC1 by KNOP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →