KNCN

Across TCGA patient cohorts, KNCN mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNCN-associated genes across cancer lineages are eIF4E, Ku80, and MEK1. Each is linked with KNCN in more than 1 cancer types. Because this analysis shows association rather than direction, both KNCN-to-partner and partner-to-KNCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KNCN-low versus KNCN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNCN→partner) and Y-score (partner→KNCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.269	+3.321	.015	.010	3	1
UCEC	Ku80 →	+0.359	+3.335	.003	.005	3	1
UCEC	MEK1 →	+0.423	+3.169	.027	.019	3	1
UCEC	TFRC →	+0.869	+3.000	.001	.036	3	1
UCEC	Tuberin →	+0.438	+3.179	.001	.010	3	1
UCEC	c-Met_pY1235 →	+0.128	+3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4E by KNCN expression — UCEC

Explore this box plot interactively →