KMT5C

Across TCGA pan-cancer cohorts, KMT5C Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KMT5C data layer compared with 28 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher KMT5C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KMT5C expression acts as an unfavorable survival marker.

LUSC and UCEC are the cancer types where KMT5C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	15	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

KMT5C–LUSC (DFS)

Open the LUSC breakdown →