KMT5C

Across TCGA pan-cancer cohorts, KMT5C RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of KMT5C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where KMT5C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KMT5C is over-expressed in tumor.

KIRP, HNSC, and KIRC are the cancer types where KMT5C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KMT5C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+1.562	<.001	11	view →
HNSC	Male	III,IV	+1.016	<.001	11	view →
KIRC	Male	IV	+0.686	<.001	11	view →
COAD	Male	IV	+1.464	<.001	10	view →
LIHC	Female	II,III,IV	+1.591	<.001	9	view →
BLCA	All	All	+0.833	<.001	9	view →
STAD	Female	All	+1.547	<.001	8	view →
LUSC	All	II,III,IV	+1.024	<.001	6	view →
UCEC	All	All	+0.737	<.001	6	view →
BRCA	All	II,III,IV	+0.447	<.001	6	view →
CHOL	Male	All	+2.263	<.001	5	view →
ESCA	All	II,III,IV	+1.724	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

KMT5C–KIRP

Open the KIRP breakdown →