KMT5C

Across TCGA patient cohorts, KMT5C mutation is significantly associated with the RNA expression of many other genes, with 3,250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT5C-associated genes across cancer lineages are RPS27P1, SEPTIN14P19, and RN7SKP93. Each is linked with KMT5C in more than 2 cancer types. Because this analysis shows association rather than direction, both KMT5C-to-partner and partner-to-KMT5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS27P1 grouped by KMT5C-low versus KMT5C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5C→partner) and Y-score (partner→KMT5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS27P1 →	+0.233	+3.562	<.001	.001	3	3
HNSC	SEPTIN14P19 →	+0.056	+4.822	<.001	.006	3	2
SKCM	RN7SKP93 →	+0.079	+3.300	<.001	.007	3	2
SKCM	RNU6-1318P →	+0.252	+3.555	<.001	.004	3	2
SKCM	SUPT20HL2 →	+0.109	+2.759	<.001	.009	3	2
SKCM	IFNWP15 →	+0.034	+4.212	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,250 associations by consensus.

RPS27P1 by KMT5C expression — SKCM

Explore this box plot interactively →