KMT5C

Across TCGA patient cohorts, KMT5C mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT5C-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and JNK_pT183_Y185. Each is linked with KMT5C in more than 1 cancer types. Because this analysis shows association rather than direction, both KMT5C-to-partner and partner-to-KMT5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KMT5C-low versus KMT5C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5C→partner) and Y-score (partner→KMT5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.605	+1.604	.011	.041	3	2
UCEC	14-3-3_beta →	-0.100	-3.143	.013	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.160	-2.115	.018	.017	3	1
UCEC	JNK2 →	+0.210	+1.906	.008	.016	3	1
UCEC	Ku80 →	+0.262	+2.472	.005	.010	3	1
UCEC	N-Ras →	-0.129	-1.893	.007	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by KMT5C expression — UCEC

Explore this box plot interactively →