KMT5C

Across TCGA cell cohorts, KMT5C RNA expression is significantly associated with the go_rna of many other GO terms, with 5,337 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible KMT5C-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Regulation of protein localization to endoplasmic reticulum. Each is linked with KMT5C in more than 17 cancer types. Because this analysis shows association rather than direction, both KMT5C-to-partner and partner-to-KMT5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by KMT5C-low versus KMT5C-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5C→partner) and Y-score (partner→KMT5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.115	+1.401	.006	<.001	2	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.103	+1.113	<.001	<.001	3	17
STOMACH	Regulation of protein localization to endoplasmic reticulum →	+0.117	+1.486	<.001	<.001	3	16
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.155	+1.066	<.001	<.001	3	16
STOMACH	Regulation of myoblast fusion →	+0.096	+1.104	.004	.002	2	17
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.101	+1.055	.001	.003	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,337 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by KMT5C expression — STOMACH

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