KMT5C

Across TCGA cell cohorts, KMT5C mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT5C-associated genes across cancer lineages are C20orf85, IL22, and CYP39A1. Each is linked with KMT5C in more than 1 cancer types. Because this analysis shows association rather than direction, both KMT5C-to-partner and partner-to-KMT5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by KMT5C-low versus KMT5C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5C→partner) and Y-score (partner→KMT5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	CYP39A1 →	+0.158	+3.769	<.001	.008	3	1
BLOOD_Leukemia	OR10R2 →	+2.104	+3.551	<.001	.009	3	1
BLOOD_Leukemia	TEX35 →	+0.202	+3.769	<.001	.008	3	1
BLOOD_Leukemia	SMIM32 →	+0.019	+4.169	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

C20orf85 by KMT5C expression — BLOOD_Leukemia

Explore this box plot interactively →