KMT5B

Across TCGA patient cohorts, KMT5B mutation is significantly associated with the RNA expression of many other genes, with 4,204 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT5B-associated genes across cancer lineages are TPI1, MIR3928, and RN7SKP230. Each is linked with KMT5B in more than 3 cancer types. Because this analysis shows association rather than direction, both KMT5B-to-partner and partner-to-KMT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPI1 grouped by KMT5B-low versus KMT5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5B→partner) and Y-score (partner→KMT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPI1 →	+0.504	+2.632	<.001	<.001	3	4
LUAD	MIR3928 →	+0.423	+3.285	<.001	.009	3	3
COAD	RN7SKP230 →	+0.688	+2.713	<.001	.004	3	3
UCEC	SSRP1 →	+0.474	+2.556	<.001	<.001	3	3
UCEC	SUPV3L1 →	+0.279	+1.818	.007	<.001	3	3
UCEC	ZNF367 →	+0.803	+2.632	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,204 associations by consensus.

TPI1 by KMT5B expression — UCEC

Explore this box plot interactively →