KMT5B

Across TCGA patient cohorts, KMT5B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT5B-associated genes across cancer lineages are Cyclin-B1, NF2, and PCNA. Each is linked with KMT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both KMT5B-to-partner and partner-to-KMT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by KMT5B-low versus KMT5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5B→partner) and Y-score (partner→KMT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.625	+2.999	<.001	<.001	3	2
UCEC	NF2 →	+0.156	+1.137	.022	.041	3	2
UCEC	PCNA →	+0.249	+2.115	<.001	<.001	3	2
UCEC	Rad50 →	-0.245	-2.308	.001	.005	3	2
COAD	Stathmin →	+0.175	+2.815	.038	.036	3	1
COAD	ASNS →	+0.981	+2.815	<.001	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Cyclin-B1 by KMT5B expression — UCEC

Explore this box plot interactively →