KMT5AP3

Across TCGA pan-cancer cohorts, KMT5AP3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KMT5AP3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KMT5AP3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KMT5AP3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, DLBC, and UCEC are the cancer types where KMT5AP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.837	0.739	.014	66	view →
DLBC	DFS	Median	II,III,IV	0.457	0.903	.002	43	view →
UCEC	DFS	Quartile	II,III,IV	0.762	0.848	.010	40	view →
THCA	OS	Tertile	All	0.937	0.989	<.001	36	view →
LIHC	DFS	Tertile	III,IV	0.133	0.368	.001	36	view →
BLCA	OS	Quartile	II,III,IV	0.809	0.656	.012	33	view →
KIRC	DFS	Median	IV	0.496	0.714	.008	31	view →
ESCA	OS	Median	All	0.449	1.000	.011	23	view →
SARC	OS	Tertile	All	0.264	0.684	<.001	18	view →
READ	OS	Median	II,III,IV	0.817	0.445	.007	18	view →
PRAD	OS	Median	All	0.976	1.000	.012	18	view →
KIRP	DFS	Tertile	All	0.563	0.816	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

KMT5AP3–HNSC (OS)

Open the HNSC breakdown →