KMT5AP3

Across TCGA pan-cancer cohorts, KMT5AP3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of KMT5AP3’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where KMT5AP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KMT5AP3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BRCA, BLCA, and STAD are the cancer types where KMT5AP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KMT5AP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	IV	+0.305	<.001	6	view →
BLCA	All	All	+0.169	.013	6	view →
STAD	All	All	+0.192	.009	4	view →
PRAD	All	All	+0.187	<.001	2	view →
THCA	All	All	−0.032	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

KMT5AP3–BRCA

Open the BRCA breakdown →