Across TCGA pan-cancer cohorts, KMT5A Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated KMT5A data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KMT5A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated KMT5A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC are the cancer types where KMT5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.956	0.628	.033	4	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: KMT5A tumor-vs-normal RNA expression · all KMT5A data types