Across TCGA patient cohorts, KMT5A mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT5A-associated genes across cancer lineages are ATM, A-Raf_pS299, and Ku80. Each is linked with KMT5A in more than 1 cancer types. Because this analysis shows association rather than direction, both KMT5A-to-partner and partner-to-KMT5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5A→partner) and Y-score (partner→KMT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.385	-1.906	.035	.016	3	2
UCEC	A-Raf_pS299 →	-0.112	-2.584	.019	.010	3	1
UCEC	Ku80 →	+0.262	+3.183	.005	.009	3	1
UCEC	MEK1 →	+0.409	+3.700	.005	.001	3	1
UCEC	Notch1 →	+0.173	+1.906	.002	.016	3	1
UCEC	P-Cadherin →	-0.163	-2.574	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

KMT5A survival (RNA) · tumor vs normal (RNA) · all KMT5A data types