Across TCGA cell cohorts, KMT5A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,457 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KMT5A-associated GO terms across cancer lineages are Signal transduction in response to DNA damage, Negative regulation of cell cycle process, and DNA integrity checkpoint signaling. Each is linked with KMT5A in more than 15 cancer types. Because this analysis shows association rather than direction, both KMT5A-to-partner and partner-to-KMT5A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5A→partner) and Y-score (partner→KMT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Signal transduction in response to DNA damage →	+0.066	+0.927	<.001	<.001	3	16
BONE	Negative regulation of cell cycle process →	+0.070	+0.725	.004	.002	3	16
LUNG_NSCLC_LUSC	DNA integrity checkpoint signaling →	+0.081	+0.987	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome organization →	+0.076	+0.939	.001	.001	3	16
SOFT_TISSUE	P-body assembly →	+0.121	+0.998	<.001	<.001	3	16
LARGE_INTESTINE	DNA damage checkpoint signaling →	+0.067	+0.983	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,457 associations by consensus.

Exploration

KMT5A survival (RNA) · tumor vs normal (RNA) · all KMT5A data types