Across TCGA cell cohorts, KMT5A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT5A-associated genes across cancer lineages are SLC5A7, KRT71, and MS4A4A. Each is linked with KMT5A in more than 1 cancer types. Because this analysis shows association rather than direction, both KMT5A-to-partner and partner-to-KMT5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5A→partner) and Y-score (partner→KMT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC5A7 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRT71 →	+0.066	+4.922	<.001	.009	3	1
LARGE_INTESTINE	MS4A4A →	+0.191	+4.000	<.001	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR2B2 →	+0.029	+3.347	.001	.005	3	1
LARGE_INTESTINE	OR52H1 →	+0.020	+3.347	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

KMT5A survival (RNA) · tumor vs normal (RNA) · all KMT5A data types