KMT2E

Across TCGA patient cohorts, KMT2E RNA expression is significantly associated with the protein abundance of many other proteins, with 16,184 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KMT2E-associated proteins across cancer lineages are STT3B_S498, GTF2I, and HNRNPU. Each is linked with KMT2E in more than 4 cancer types. Because this analysis shows association rather than direction, both KMT2E-to-partner and partner-to-KMT2E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KMT2E versus STT3B_S498 in PDAC, with a Pearson correlation of -0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2E→partner) and Y-score (partner→KMT2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	STT3B_S498 →	-0.646	-0.318	<.001	<.001	3	5
LSCC	GTF2I →	+0.474	+0.482	<.001	<.001	3	5
HNSC	HNRNPU →	+0.274	+0.795	<.001	<.001	3	5
GBM	MAN2A1 →	-0.559	-0.466	<.001	<.001	3	5
LSCC	MEPCE →	+0.351	+0.363	<.001	.003	3	5
PDAC	MGAT2 →	-0.487	-0.456	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,184 associations by consensus.

KMT2E vs STT3B_S498 — PDAC

Explore this scatter interactively →