KMT2E

Across TCGA patient cohorts, KMT2E mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT2E-associated genes across cancer lineages are 4E-BP1, Caspase-7-cleavedD198, and eEF2. Each is linked with KMT2E in more than 2 cancer types. Because this analysis shows association rather than direction, both KMT2E-to-partner and partner-to-KMT2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KMT2E-low versus KMT2E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2E→partner) and Y-score (partner→KMT2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.376	+1.678	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.438	+3.178	<.001	.010	3	3
UCEC	eEF2 →	+0.283	+1.494	.004	.001	3	3
UCEC	JNK2 →	+0.241	+1.678	<.001	<.001	3	3
UCEC	PCNA →	+0.156	+1.678	.009	.019	3	3
UCEC	C-Raf →	+0.146	+1.716	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

4E-BP1 by KMT2E expression — UCEC

Explore this box plot interactively →