KMT2E

Across TCGA cell cohorts, KMT2E RNA expression is significantly associated with the go_rna of many other GO terms, with 4,731 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KMT2E-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Pre-mRNA catabolic process, and Regulation of nucleotide-excision repair. Each is linked with KMT2E in more than 15 cancer types. Because this analysis shows association rather than direction, both KMT2E-to-partner and partner-to-KMT2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by KMT2E-low versus KMT2E-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2E→partner) and Y-score (partner→KMT2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome condensation →	+0.135	+0.719	.001	.007	2	16
BONE	Pre-mRNA catabolic process →	+0.199	+0.591	<.001	.001	3	15
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.118	+0.681	<.001	<.001	3	15
KIDNEY	Peptidyl-serine phosphorylation →	+0.091	+0.953	<.001	.001	3	14
BREAST	Regulation of hematopoietic stem cell differentiation →	+0.126	+1.249	<.001	<.001	3	14
SOFT_TISSUE	Positive regulation of mRNA metabolic process →	+0.062	+0.785	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,731 associations by consensus.

Negative regulation of chromosome condensation by KMT2E expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →