KMT2E

Across TCGA cell cohorts, KMT2E mutation is significantly associated with the RNA expression of many other genes, with 656 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KMT2E-associated genes across cancer lineages are B3GNT4, NPY5R, and OR7G3. Each is linked with KMT2E in more than 1 cancer types. Because this analysis shows association rather than direction, both KMT2E-to-partner and partner-to-KMT2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B3GNT4 grouped by KMT2E-low versus KMT2E-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT2E→partner) and Y-score (partner→KMT2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	B3GNT4 →	+0.673	+3.036	<.001	<.001	3	2
BLOOD_Myeloma	NPY5R →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR7G3 →	+0.886	+4.807	.001	.006	3	1
BLOOD_Myeloma	OR6C70 →	+0.073	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FOXB2 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	RPTN →	+0.013	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 656 associations by consensus.

B3GNT4 by KMT2E expression — LARGE_INTESTINE

Explore this box plot interactively →